Endocrine Abstracts

Background: The onset of type 1 diabetes before menarche was a risk factor for the subsequent development of hyperandrogenic disorders. It has been also suggested that the use of exogenous insulin to treat type 1 diabetes mellitus in those patients may contribute to the development of PCOS. Abnormal lipid levels were also reported in children with type 1 diabetes mellitus during pubertal years.Aim of work: This study was designed to investigate metabolic...

Background: Fractalkine (CX3CL1) is known to convey its signals through a single G-protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals.<p class=...